Expert in molecular dynamics and near?field optical microscopy
Harry Heinzelmann
Probe Array Technology for Life Science Applications

Expert in functionalization, CL array microfabrication and functionalization, top-down fabrication methods for nanowires
Jürgen Brugger
Expert in microsensors, microfluidics and  
Nico De Rooij
Expert in micro-optics and photonic crystal-based sensors
Hans Peter Herzig
UNIL/Centre Pluridisciplinaire d'Oncologie
Expert in Membrane microdomains
Agnese Mariotti
Expert in Functionalization/Sensing
Ernst Meyer
UNIL/Biology and Medecine
Expert in Cancer immunology and immunotherapy
Pedro Romero
Expert in vesicle & cell arrays
Horst Vogel

Project Description

Methods that allow the routine, early, non-invasive detection of cancer willallow early treatment with better survival rates. The development oflaboratory tools for the screening of cancer drugs on a cell level, allowing monitoring the cells’ adhesion and biomechanical responses, represent promising paths in the search of cancer therapies. The projects objectives include the optimization of nanomechanical sensing for early cancer detection, with a case study for head and neck cancer patients. Further, parallel force spectroscopy is being developed that allow the statistically relevant examination of the nanomechanical responses of numerous cells simultaneously. 

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Our researchers in the media

Notable publications

Real-Time Viscosity and Mass Density Sensors Requiring Microliter Sample Volume Based on Nanomechanical Resonators
BA Bircher, L Duempelmann, K Renggli, HP Lang, C Gerber, N Bruns, T Braun
Analytical chemistry 85 (18), 8676-8683 (2013)

Development of Robust and Standardized Cantilever Sensors Based on Biotin/Neutravidin Coupling for Antibody Detection
J Zhang, HP Lang, F Battiston, N Backmann, F Huber, C Gerber
Sensors 13 (4), 5273-5285 (2013)

Direct detection of a BRAF mutation in total RNA from melanoma cells using cantilever arrays
F Huber, HP Lang, N Backmann, D Rimoldi, C Gerber
Nature nanotechnology 8 (2), 125-129 (2013)

Piezoresistive Membrane-Type Surface Stress Sensor Arranged In Arrays For Cancer Diagnosis Through Breath Analysis
F. Loizeau, H.P. Lang, T. Akiyama, S. Gautsch, P. Vettiger, A. Tonin, G. Yoshikawa, Ch. Gerber, N. de Rooij
Proc. 26th IEEE International Conference On Micro Electro Mechanical Systems MEMS 2013, p. 621-624 (2013)


Posters from 2014

Nanomechanical membrane sensors for non-invasive analysis of exhaled breath samples from cancer patients
Hans Peter Lang, Frederic Loizeau, Agnes Hiou, Pedro Romero, Teru Akiyama, Sebastian Gautsch, Christoph Gerber, Ernst Meyer

High aspect ratio SU-8 tips for cost-efficient bio-probe fabrication
Jonas Henriksson, Giovanni Boero, Jürgen Brugger

Posters from 2013

Microfabricated sensor arrays for life science applications
Frédéric Loizeau, Terunobu Akiyama, Sebastian Gautsch, Hans Peter Lang, André Meister, Peter Vettiger, Genki Yoshikawa, Nico de Rooij

Melanoma Diagnostics with Nanomechanical Biosensors
François Huber, Natalija Backmann, Jiayun Zhang, Donata Rimoldi, Hans Peter Lang, Christoph Gerber

Antibody recognition of tumor cells on the cantilever surface
Jiayun Zhang, François Huber, Donata Rimoldi, Hans Peter Lang, Christoph Gerber

Individually actuated cantilever arrays for cell force spectroscopy
Jonas Henriksson, Maurizio Gullo, Juergen Brugger

Posters from 2012

Nanomechanical membrane surface stress sensors for medical breath testing
Lang, Tonin, Huber, Backmann, Gautsch, Loizeau, Akiyama, Rimoldi, Mariotti, Romero, Heinzelmann, Gerber, Meyer

Personalized medical diagnostics based on nanomechanics
Huber, Backmann, Lang, Zhang, Rimoldi, Despont, Drechsler, Heinzelmann, Gerber, Meyer

Cantilever array sensing of tumor cells
Backmann, Huber, Lang, Rimoldi, Gerber, Meyer

Microfluidic tools for novel cell applications
Martinez-Duarte, Buffi, Renaud


Posters from 2011

Parallel AFM Force Spectroscopy on Melanoma Cells for Cancer Research

Integrated MEMS actuation for force spectroscopy in liquid
Jonas Henriksson, Maurizio Gullo, J

Nanomechanical sensing of tumor cells circulating in blood; cell, mRNA and DNA detection


Project Photos